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Updated: Jul 8, 2025

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
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失去VHL可以通过促进I型干扰素反应来实现免疫检查点阻塞疗法

Meng Jiao, Xuhui Bao, Mengjie Hu

    bioRxiv : the preprint server for biology
    |December 11, 2023
    PubMed
    概括

    在清细胞细胞癌 (ccRCC) 中失去希佩尔-林道 (VHL) 基因可以提高抗PD-1疗法的有效性. VHL基因损失通过释放线粒体DNA触发免疫反应,增强免疫治疗结果.

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