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皮质有机体支持常存记忆CD8 T细胞分化

Max R Ulibarri¹, Ying Lin^1,2, Julian R Ramprashad¹

¹Department of Molecular Microbiology and Immunology, Brown University, Providence, RI, 02912.

bioRxiv : the preprint server for biology

|December 11, 2023

概括

我们开发了一种新的体外模型,使用阴道上皮器官 (VEO) 和CD8T细胞来研究居住记忆T细胞 (TRM). 该系统可实现TRM差异化和功能的可扩展,高吞吐量分析.

科学领域:

免疫学免疫学免疫学
细胞生物学细胞生物学
有机物技术有机物技术

背景情况:

居民记忆T细胞 (TRM) 对于在障碍站点的免疫是至关重要的.
在体内研究TRM是具有挑战性的,因为隔离困难和低细胞存活率.
现有的模型限制了TRM生物学的高通量分析.

结论:

建立了一个强大的,可扩展的体外模型来研究TRM分化.
该模型促进了高通量测试,以更深入地了解TRM生物学.
能够在减少主义环境中对抗病毒CD8T细胞反应进行详细的调查.

关键词:

CD8 寄居记忆T 细胞阴道上皮质有机体在体外分化的 in vitro差异化.

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