速度和稳健性之间的权衡在原始启动中通过auxin-CUC1相互作用介导
Shuyao Kong1,2, Mingyuan Zhu1,2,3, David Pan1,2
1Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA.
bioRxiv : the preprint server for biology
|December 11, 2023
概括
植物发育中的坚固性,就像Arabidopsis中的分离体形成一样,可以因发育噪声而受损. CUC1 (CUP-SHAPED COTYLEDON1) 放大了这种噪音,但减少它的表达可以恢复强度,以牺牲速度.
科学领域:
- 发展生物学 发展生物学
- 植物科学 植物科学
- 系统生物学 系统生物学
背景情况:
- 发育强度确保了尽管有生物噪音,可复制的表型.
- 强度与其他绩效指标之间的权衡是常见的,但在机制上不清楚.
- 阿拉比多普西斯的花朵发育依赖于精确的auxin最大值,以实现强大的分离开端.
研究的目的:
- 调查在drmy1突变体中丧失分离启动强度的背后机制.
- 阐明CUP-SHAPED COTYLEDON1 (CUC1) 在调解发育噪声和强度方面的作用.
- 探索发展速度和强度之间的权衡.
主要方法:
- 对阿拉比多普西斯突变物 (drmy1,CUC1) 的遗传分析.
- 对auxin信号传递动态和分离原体定位的分析.
- 对辅助素运输和发育过程的计算建模.
主要成果:
- 在drmy1突变体中增加的CUC1表达会放大辅酶信号噪声,导致可变的分离启动.
- 减少drmy1中的CUC1通过允许辅酶信号稳定,恢复了强度,但减缓了分离开始.
- CUC1对PIN1极化的影响解释了观察到的表型;减少的全球增长增强了强度.
结论:
- CUC1作为一个关键的调节器,平衡发育速度和强度与辅酶噪声.
- 这项研究揭示了转录因子 (CUC1) 和速度-稳定性权衡之间的直接联系.
- 研究结果强调了噪声放大/缓冲和发育效率之间的相互作用.
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