像Myc这样的MLX网络影响衰老和新陈代谢
Huabo Wang1, Taylor Stevens1, Jie Lu1
1Division of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh.
bioRxiv : the preprint server for biology
|December 11, 2023
概括
类似于Myc的Mlx网络影响着衰老和新陈代谢. Mlx无活化加速老化表型,突出其在维持健康的关键作用.
科学领域:
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
- 衰老研究研究 衰老研究
背景情况:
- Myc 和 Mlx 网络是调节基本细胞过程的关键转录因子网络.
- 这两个网络都有共同的基因标,并且需要特定的异体化合作伙伴来进行活动.
研究的目的:
- 调查MIX网络在衰老过程中的作用.
- 为了比较Mlx无活化与Myc无活化对老化表型和寿命的影响.
主要方法:
- 在小鼠 (MlxKO) 中全身激活Mlx基因.
- 在MlxKO小鼠中分析与衰老相关的表型,基因表达和癌症发病率.
- 与现有的Myc淘汰 (MycKO) 鼠标数据进行比较.
主要成果:
- Mlx无活化加快了与身体组成和新陈代谢相关的衰老表型.
- 与衰老相关的基因组的放松调节,包括控制核糖体和线粒体功能的基因组,通过Mlx无活化加速.
- MlxKO小鼠表现出正常寿命和略有增加的癌症发病率,与MycKO小鼠形成对比,这些小鼠表现出延长寿命和减少癌症发病率.
- 在老鼠和人类中,Mlx,Myc,MondoA,ChREBP及其目标基因的表达随着年龄的增长而下降.
结论:
- Mlx网络在调节衰老和新陈代谢方面发挥着重要作用,与Myc网络的功能并行.
- 随着年龄的增长,Mlx,MondoA和ChREBP表达的恶化在老鼠和人类中都突显出持续网络活动对健康衰老的重要性.
- Myc 和 Mlx 网络之间的平衡交叉交谈对于维持正常的衰老过程在整个生命过程中至关重要.
关键词:
癌症的代谢 癌症的代谢造成的DNA损伤是DNA损伤.线粒体中的线粒体.迈克 (Myc) 是一个非常有价值的人.在TCA循环中,TCA循环的周期是:华堡效应是什么? 华堡效应有活性氧物种的反应性氧物种.端粒是什么意思 端粒是什么意思更多相关视频
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