DDX3X和DDX3Y组合形成纳米大小的RNA-蛋白质集群,促进酶活性
bioRxiv : the preprint server for biology
|December 11, 2023
概括
死亡盒螺旋酶形成RNA-蛋白质集群 (RPCs),对RNA代谢至关重要. 这些集群由内在无序区域 (IDR) 促进,增强酶活性,可能是RNA解和应激反应的关键.
科学领域:
- 分子生物学分子生物学
- 生物化学 生物化学
- 细胞生物学 细胞生物学
背景情况:
- 死亡盒螺旋酶对RNA代谢至关重要,通常具有具有未知的功能的内在失序区域 (IDR).
- 由性别染色体编码的同源RNA基酶DDX3X和DDX3Y是这个重要的家族的成员.
结论:
- 在正常条件下,纳米尺寸的螺旋酶RPC代表了DEAD-box螺旋酶的功能状态,促进RNA解.
- 这些RPC可以在细胞应激下作为液体-液体相分离的核化场所.
- 这些发现表明,在整个家族中,DEAD-box酶调节的保护机制存在.
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