在空间扩张的群体中选择性扫除概率
Alexander Stein1, Ramanarayanan Kizhuttil2, Maciej Bak3
1Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK and Department of Physics, ETH Zurich, Zürich, Switzerland.
bioRxiv : the preprint server for biology
|December 11, 2023
概括
有益的突变可以横扫不断扩大的群体,但在已建立的瘤中这是罕见的. 新的模型预测了独立于突变率的横扫概率,为癌症进化提供了洞察力.
科学领域:
- 进化生物学是进化的生物学.
- 数学建模的数学建模
背景情况:
- 范围的扩大对于塑造生物系统至关重要,从微生物到入侵物种.
- 一个关键的问题是,有益的突变能否在扩张过程中克服克隆干扰.
- 现有的模型往往简化范围扩展或忽略空间结构.
结论:
- 在成熟的人类瘤中,选择性扫描很少发生,这解释了最近的测序发现.
- 模型为扫描的稀有性提供了一个一般的泛癌解释.
- 洞察力适用于正在经历范围扩张的各种生物系统.
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