相关实验视频
Updated: Jul 8, 2025

04:48
Control of Eating Behavior Using a Novel Feedback System
Published on: May 8, 2018
11.0K
通过食物的味道来控制饥饿回路的负反控制
Tara J Aitken1, Truong Ly1, Sarah Shehata2
1Neuroscience Graduate Program, University of California, San Francisco; San Francisco, CA 94158, USA.
bioRxiv : the preprint server for biology
|December 11, 2023
概括
味觉信号在吃饭时迅速抑制促进饥饿的AgRP神经元. 这种由味道驱动的腹机制,涉及背中侧下丘脑,控制食物摄入和结束饮食.
科学领域:
- 神经科学是一个神经科学.
- 生理学 生理学 生理学
- 行为科学 行为科学
背景情况:
- 食物有奖励的味道驱动了饮食行为.
- 味觉在信号中扮演的角色 结束饭菜和腹感还没有完全理解.
研究的目的:
- 研究味道在摄入负反控制中的作用.
- 阐明味道影响食行为和腹感的神经机制.
主要方法:
- 利用闭环光遗传刺激来操纵神经元活动 in vivo.
- 在动物模型中,在养行为期间记录了下丘脑区域的神经元活动.
- 研究了背中中垂体中受体表达神经元 (DMH/LepR) 的功能.
主要成果:
- 促进饥饿的AgRP神经元在摄入食物时被味道信号迅速抑制.
- 阻止这些味道诱导的抑制信号会延迟和感,增加食物摄入量.
- 背中下丘脑 (DMHLepR) 神经元显示调味激活,反映了AgRP神经元的抑制.
结论:
- 味觉在对食物摄入的负反控制中起着至关重要的作用.
- 一个神经回路涉及味觉,DMHLepR神经元和AgRP神经元,调节时刻的食动态和腹感.
相关概念视频
Regulation of Food Intake
239
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
239
The Physiology of Taste
3.9K
The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the...
3.9K
Feedback Loops
57.6K
In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
57.6K
Gustation
48.1K
Gustation is a chemical sense that, along with olfaction (smell), contributes to our perception of taste. It starts with the activation of receptors by chemical compounds (tastants) dissolved in the saliva. The saliva and filiform papillae on the tongue distribute the tastants and increase their exposure to the taste receptors.
48.1K
Taste Buds and Receptors
2.0K
Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
2.0K
Neural Regulation
39.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.5K

