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分子动力学模拟提供了ULK-101的强度和对自激酶ULK1/2的选择性的洞察力

Robert M Vaughan1, Bradley M Dickson2, Katie R Martin1

  • 1Pediatrics and Human Development, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503, USA.

bioRxiv : the preprint server for biology
|December 11, 2023
PubMed
概括

分子动力学模拟揭示了ULK-101如何与ULK2激酶结合. 这种小分子抑制剂向ATP结合部位,诱导强烈和选择性抑制的特定构造.

关键词:
在ULK-101中,ULK1 是一个ULK1ULK2 ULK2 ULK2 ULK2 ULK2 ULK2 ULK2 ULK2 ULK2 ULK2自自是自的过程.激酶激酶的作用是什么分子动力学分子动力学小分子抑制剂小分子抑制剂

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