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饮食作为炎症性肠病的表观遗传因素
Karina Marangoni1,2, Gilson Dorneles3, Daniella Miranda da Silva4,5
1Egas Moniz School of Health and Science, Caparica - Almada, Portugal, Caparica 2820-062, Portugal.
饮食干预可以通过调节肠道微生物和表观遗传学来中断炎症性肠病 (IBD) 的炎症循环. 营养策略是管理IBD活动和改善患者结果的关键.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 炎症性肠病 (IBD) 涉及免疫系统对肠道细胞过度活跃,破坏肠道微生物群.
- 这导致营养缺乏,免疫力受损,预后更差,从而形成一个有害的循环.
- 饮食模式通过与肠道微生物群和表观基因组相互作用,显著影响IBD.
研究的目的:
- 审查饮食化合物如何影响表观遗传修饰.
- 探索表观遗传学在IBD患者肠道微生物群调节中的作用.
- 突出营养干预在治疗IBD中的重要性.
主要方法:
- 文献综述侧重于IBD中饮食,表观遗传学和肠道微生物群之间的相互作用.
- 对研究饮食化合物及其表观遗传效应的研究进行分析.
- 综合当前对IBD管理营养策略的理解.
主要成果:
- 饮食干预可以打断IBD炎症,营养缺乏和免疫功能障碍的恶性循环.
- 特定的营养和饮食模式可以诱导表观遗传变化.
- 这些表观遗传修饰反过来又会影响肠道微生物群的组成和功能.
结论:
- 营养干预对于预防和管理IBD活动至关重要.
- 由饮食化合物诱导的表观遗传修饰提供了一个调节IBD肠道微生物群的机制.
- 针对饮食,表观基因组和微生物群之间的相互作用具有IBD的治疗潜力.
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