精神分裂症中网络内部和网络之间的功能连接性改变:一项回顾性研究
Farzaneh Keyvanfard1, Anna-Katharina Schmid2, Abbas Nasiraei-Moghaddam3
1School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran.
精神分裂症患者的脑内网络连接显著减少,特别是在体运动,视觉和腹部注意力网络中. 这些发现突出了大脑网络中导致疾病的关键干扰.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 精神分裂症 (SZ) 是一种慢性大脑疾病,其特征是由于大脑异常连接导致的认知缺陷.
- 评估内部和网络之间的连接变化对于理解SZ中信息处理中断至关重要.
研究的目的:
- 研究精神分裂症患者在静止状态网络 (RSN) 内和之间功能性大脑连接的变化.
- 确定特定的RSN和连接类型 (内部与内部网络) 在精神分裂症中最受影响.
主要方法:
- 在休息状态功能磁共振成像 (fMRI) 进行了24名SZ患者和27名健康对照.
- 建立了功能连接矩阵,并将区域分为八个不同的RSN.
- 连接权重和节点强度分析了网络内部和网络内部连接.
主要成果:
- 脊髓炎患者在体力运动网络中显著减少了网络内连接 (P<0.001).
- 在视觉和腹部注意力 (VA) 网络中,内部网络连接明显较低 (P<0.01).
- 在视觉边缘,体运动边缘,背部注意力边缘和腹部注意力-背部注意力系统之间观察到网络内部连接的中断.
结论:
- 精神分裂症的特点是功能连接强度的广泛减少,网络内部连接比网络内部连接更受影响.
- 在SZ患者中,边缘系统与多个RSN的相互作用显著改变.
- 这些发现提供了关于精神分裂症背后的特定连接失调的见解,可能有助于诊断和治疗策略.
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