在帕杰特病中前列腺特异性抗原升高
Shrikant Vasantrao Solav1, Manohar Inamdar2, Shailendra V Savale2
1Department of Nuclear Medicine, SPECTLAB Nuclear Medicine Services, Pune, India.
概括
一个前列腺癌患者.
科学领域:
- 在瘤学瘤学.
- 核医学是一种核医学.
- 放射学 放射学是指放射学
背景情况:
- 一名患有晚期前列腺癌 (Gleason 8) 的70岁老人呈现出前列腺特异抗原 (PSA) 的升高.
- 进行骨扫描,以评估骨转移.
研究的目的:
- 评估-68-前列腺特异性膜抗原 (PSMA) 子发射断层扫描 - 计算机断层扫描 (PET-CT) 在区分前列腺癌和帕杰特病中的实用性.
- 评估前列腺癌病变中的PSMA狂热度与暗示帕杰特病的硬化骨病变.
主要方法:
- 由于血清PSA水平升高 (224 ng/mL),进行了骨扫描.
- -68-PSMA PET-CT进行了进一步的骨发现和前列腺特征.
- 图像检测结果与临床表现和组织病理学 (隐含) 相相关.
主要成果:
- 骨扫描显示,右半骨中扩散的标记物吸收,模仿了帕杰特病.
- 加-68-PSMA PET-CT 检测出前列腺内有一种与前列腺癌相一致的 PSMA-avid 病变.
- 关键的是,右半的硬化区域没有显示PSMA吸收,排除了前列腺癌转移,并证实了帕杰特病.
结论:
- -68-PSMA PET-CT 是一个有价值的工具,用于区分前列腺癌和帕杰特病在含糊不清的骨扫描患者.
- 在硬化骨病变中没有PSMA吸收,有效地排除了前列腺癌的参与,促进了准确的诊断和适当的管理.
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