相关实验视频

Updated: Jul 31, 2026

Optimized Protocol for Efficient Transfection of Dendritic Cells without Cell Maturation
08:08

Optimized Protocol for Efficient Transfection of Dendritic Cells without Cell Maturation

Published on: July 8, 2011

20.4K

内体贩运抑制剂EGA可以控制人类血细胞状树突细胞的TLR7介导的IFNα表达

Matthew J Wiest1, Laurie Baert1, Chao Gu1

  • 1Department of Immunology, Mayo Clinic, Scottsdale, AZ, United States.

Frontiers in immunology
|December 11, 2023
PubMed
概括

作为一种晚期内分体抑制剂,EGA可降低血细胞 dendritic 细胞 (pDCs) 的1型干扰素产量. 这表明,将TLR7主激素贩运向LAMP1+区块的向可以治疗自身免疫性疾病.

关键词:
美国EGAGA在TLR7中,内体内体贩运 贩卖内体内体具有天生的免疫力.核酸核酸是一种核酸.血细胞状的树突细胞细胞.有关炎症的细胞因子.一种类型的干扰素-1型干扰素.

更多相关视频

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

10.7K
Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

7.5K

相关概念视频

Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR activation may...
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...