通过寄生虫虫产品ES-62在小鼠的肥胖加速衰老期间保护肺部病理
Margaret M Harnett1, Felicity E Lumb2, Jenny Crowe1
1School of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom.
Frontiers in immunology
|December 11, 2023
概括
寄生虫虫蛋白质ES-62保护雄性小鼠的肺部免受高热量饮食加速衰老的病理影响. 它的类似物也显示肺部保护和减少炎症,表明治疗潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 衰老研究研究 衰老研究
- 寄生虫学的寄生虫学
背景情况:
- 衰老加剧了肺部病理,可能被高热量饮食 (HCD) 加速.
- 寄生虫虫蛋白ES-62具有由于醇胆 (PC) 部分而具有免疫调节特性.
- 了解与年龄相关的肺部疾病和潜在的干预措施至关重要.
研究的目的:
- 研究ES-62及其类似物对老化小鼠中HCD加速肺病理的保护作用.
- 确定ES-62对肺部炎症标志物的影响.
- 为了探索ES-62的保护作用的性别特异性差异.
主要方法:
- 每周给ES-62给C57BL/6J小鼠,小鼠从10周大时开始食HCD.
- 评估肺部病理,包括细胞透和气道改造.
- 对炎症性细胞因子 (IL-4,IL-17,IL-5) 和MyD88.5的基因表达的测量.
主要成果:
- ES-62保护雄性小鼠肺部免受HCD诱导的病理 (细胞透,呼吸道重塑) 长达160天.
- 在雄性小鼠肺中,ES-62降低了IL-4,IL-17和MyD88基因表达.
- 两种基于ES-62 PC的小分子类似物 (SMA) 在雄性小鼠中模拟了保护作用,包括减少IL-5表达.
结论:
- ES-62及其SMA提供了对HCD加速肺衰老病理的保护,特别是在男性中.
- 保护机制包括调节Th2细胞因子和IL-17.
- 这些发现表明ES-62及其类似物在与年龄相关的肺部疾病和喘中的潜在治疗应用.
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