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不同代谢标志物与门诊高尿血症患者群体中的代谢综合征之间的关联:一项横截面研究

Xin Li¹, Bo Huang¹, Yue Liu¹

¹Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.

Diabetes, metabolic syndrome and obesity : targets and therapy

|December 11, 2023

概括

甘油三糖 (TyG) 指数是查高尿血症患者代谢综合征 (MetS) 的强有力的指标. 该指数可以帮助标准化管理高尿酸水平的个体.

科学领域:

内分泌学在内分泌学.
代谢障碍代谢障碍代谢障碍
临床生物化学临床生物化学

背景情况:

超尿血症 (HUA) 经常与代谢综合征 (MetS) 相关.
在HUA门诊患者中对MetS查各种代谢标志物的实用性仍然不清楚.
这项研究调查了HUA患者不同代谢指数和MetS之间的关系.

研究的目的:

评估代谢标志物 (SUA/Cr,UHR,THR,TyG指数) 与高尿血症患者中MetS患病率之间的关联.
在这个人群中确定最有效的代谢标志物用于MetS查.
为HUA门诊患者的标准化管理提供见解.

主要方法:

分析了399名高尿血患者的队列.
收集了人口统计,人体测量和生物化学数据.
血清尿酸与肌素的比率 (SUA/Cr),尿酸与高密度脂蛋白胆固醇的比率 (UHR),甘油三与高密度脂蛋白胆固醇的比率 (THR) 以及甘油三和葡萄糖 (TyG) 指数被计算出来.
使用二进制物流回归来评估与MetS.的关联.

主要成果:

代谢综合征在28.3%的受试者中存在.
在MetS患者中,UHR,THR和TyG指数显著更高.
泰格指数显示出与MetS风险的最强相关性 (OR 5.476,95% CI 2.210-13.569).
SUA/Cr与MetS没有显著的关联.
为了预测MetS,TyG指数的最佳切断值为9.13 (AUC为0.719).

结论:

较高的TyG指数与患有高尿路血症的患者的MetS风险增加显著相关.
TyG指数是对HUA个体的MetS查的一个有价值的工具.
研究结果支持改善和标准化HUA门诊患者的管理策略.

关键词:

在TyG指数中,TyG是指数.代谢综合征代谢综合征血清尿酸转化为高密度脂蛋白胆固醇血清尿酸与肌素的比率是血清尿酸与肌素的比率.甘油三酸转化为高密度脂蛋白胆固醇.

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