人体肠道微生物组与疾病之间的相关性
Barkha Madhogaria1, Priyanka Bhowmik2, Atreyee Kundu1
1Department of Microbiology, Techno India University, West Bengal EM-4 Sector-V, Salt Lake City, Kolkata 700091, West Bengal, India.
Infectious medicine
|December 11, 2023
概括
人的肠道微生物群显著影响健康,失衡 (失生症) 与糖尿病和癌症等众多疾病有关. 研究正在进步,以了解这些复杂的肠道微生物连接及其在疾病中的作用.
科学领域:
- 微生物学 微生物学
- 人类健康 人类健康 人类健康
- 疾病病因学 疾病病因学
背景情况:
- 人的肠道微生物群包括一个巨大的细菌群体,影响健康和疾病.
- 肠道微生物的组成在健康个体和患有疾病的人之间有所不同.
- 肠道微生物群失生症与各种疾病有关,包括代谢障碍,癌症和神经系统疾病.
研究的目的:
- 审查最近关于肠道微生物组失调和疾病病因之间的联系的研究.
- 要突出不断发展的研究方法,以了解肠道微生物群在宿主新陈代谢中的作用.
- 探索肠道微生物群与疾病相关性背后的分子机制.
主要方法:
- 对英语电子数据库 (PubMed,谷歌学者等) 的广泛文献调查. ) 的情况.
- 专注于最近研究肠道微生物组失调和疾病的研究.
- 集成高吞吐量欧米克数据分析 (元基因组学,代谢组学).
主要成果:
- 肠道微生物组失调与许多疾病的发病有关,包括2型糖尿病,肥胖,非酒精性肝病,心脏代谢性疾病,癌症,关节炎,自闭症,抑郁症和高血压.
- 研究已经从描述性分析转移到研究宿主新陈代谢的整合性奥米学方法.
- 分子机制正在人类,动物和细胞模型中进行研究.
结论:
- 肠道微生物组失调是广泛的人类疾病病因的一个重要因素.
- 先进的OMIC技术对于揭示肠道微生物群和宿主健康之间的复杂相互作用至关重要.
- 需要进一步的研究,以充分阐明涉及的分子机制.
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