抗生素耐药性菌根结核病的趋势和进展以及与人类免疫缺陷病毒相关的基因
N G Mbewana Ntshanka1, T A M Msagati1
1College of Science, Engineering and Technology, Institute for Nanotechnology and Water Sustainability University of South Africa Science Campus Roodepoort, 1709 Johannesburg, South Africa.
概括
人类免疫缺陷病毒/获得免疫缺陷综合征 (艾滋病) 和结核病 (结核病) 患者的抗生素耐药性是一个日益严重的全球问题. 本综述审查了趋势,策略和COVID-19的情况.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 人类免疫缺陷病毒/获得性免疫缺陷综合征 (艾滋病毒/艾滋病) 和结核病 (结核病) 是全球死亡的主要原因.
- 结核病和艾滋病毒人群中抗生素耐药性的流行病学,特别是在南非,需要进行彻底的调查.
- 多抗药性结核病 (MDR-TB) 和广泛抗药性结核病 (XDR-TB) 的病例在全球范围内不断增加,这构成了重大的公共卫生挑战.
研究的目的:
- 提供对结核病和抗艾滋病毒菌株发展趋势和进展的深入审查.
- 突出解决这些人群中抗菌素耐药性 (AMR) 的日益严重问题的策略.
- 为了强调COVID-19流行病对AMR的影响.
主要方法:
- 文献综述,重点关注抗菌素耐药性的趋势.
- 对导致抗性菌株演变和传播的因素的分析.
- 检查全球卫生事件对AMR的影响.
主要成果:
- 抗菌剂的滥用在人类医学,农业和畜牧业中加快了抗菌剂的耐药性.
- 快速的进化,突变和水平基因转移对AMR有着显著的贡献.
- 艾滋病毒/艾滋病发病率高的人群是AMR传播的特别脆弱的热点.
结论:
- 结核病和艾滋病毒人群中抗生素耐药性日益增加,超过了新抗菌药物的开发速度.
- 迫切需要有效的战略来打击MDR-TB和XDR-TB的传播.
- COVID-19 流行病可能进一步放大了AMR危机,需要进一步的研究和干预.
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