描述埃塞俄比亚多药耐药结核病死亡的描述
E Tesema1, Z G Dememew2, D G Datiko2
1United States Agency for International Development (USAID) Eliminate TB Project, KNCV, Addis Ababa, Ethiopia.
Public health action
|December 11, 2023
概括
埃塞俄比亚使用二线药物治疗的多药耐药结核病 (MDR-TB) 死亡人数在2015年至2022年之间略有变化. 在这两项研究期间,患者的特征和不良事件有所不同.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- 耐多药结核病 (MDR-TB) 构成了重大的全球卫生挑战,需要使用二线抗结核药物.
- 埃塞俄比亚面临着大量的MDR-TB负担,患者的治疗结果受到治疗方案和临床因素的影响.
研究的目的:
- 分析埃塞俄比亚MDR-TB治疗二线抗结核药物患者死亡率和患者特征的趋势.
- 为了比较两个不同的队列在不同的时间段接受治疗之间的结果和不良事件.
主要方法:
- 对来自埃塞俄比亚的两个患者队伍的回顾性分析,一个在2015年,另一个在2022年.
- 数据收集包括死亡率,患者人口统计,并发症,治疗史和特定的临床指标.
主要成果:
- 2015年死亡率为5.4% (38/704) 在2022年为4.4% (44/995).
- 与2022年队伍相比,2015年队伍的先前治疗和低血糖率较高,但严重营养不良的患病率较低,Xpert® MTB/RIF测定使用,呼吸衰竭和严重贫血/泛贫血的患病率较低.
结论:
- 在两组患者之间观察到患者特征和不良事件的显著差异,可能受治疗方案和诊断能力的变化影响.
- 持续执行最新的临床指南对于优化患者护理和MDR-TB治疗结果至关重要.
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