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血管内皮生长因子B通过胰岛素介导的抑制葡萄糖分泌来改善受损的葡萄糖耐受性

Yu-Qi Li¹, Lu-Yang Zhang², Yu-Chi Zhao³

¹Department of Pathophysiology, School of Basic Medicine, Binzhou Medical University, Yantai 264000, Shandong Province, China.

World journal of diabetes

|December 11, 2023

概括

血管内皮生长因子B (VEGFB) 通过影响胰岛素和葡萄糖,有助于调节受损葡萄糖耐受性 (IGT) 的血糖. 在IGT小鼠中,VEGFB激活PI3K/AKT通路,减少葡萄糖并改善葡萄糖代谢.

科学领域:

内分泌学在内分泌学.
分子生物学分子生物学
代谢研究研究代谢研究

背景情况:

降低葡萄糖耐受性 (IGT) 表示糖尿病前期状态,胰岛素敏感性降低,胰岛素/葡萄糖分泌量改变.
血管内皮生长因子B (VEGFB) 显示出改善葡萄糖代谢和胰岛素敏感性的潜力.
了解VEGFB在IGT中的作用对于预防和治疗糖尿病前期至关重要.

研究的目的:

研究VEGFB在IGT小鼠中调节胰岛素介导的葡萄糖分泌中的分子机制.
在高脂肪饮食诱导的IGT小鼠模型中确定VEGFB对葡萄糖代谢的影响.

主要方法:

使用高脂肪饮食构建了一个IGT小鼠模型.
进行了VEGFB淘汰和胰腺特异性VEGFB过度表达in vivo.
量化胰岛素和葡萄糖分泌,PI3K/AKT通路激活,以及关键的葡萄糖原基因表达.

主要成果:

在IGT小鼠中,VEGFB淘汰导致葡萄糖分的增加和PI3K/AKT蛋白表达的降低.
在IGT小鼠中,VEGFB过度表达导致葡萄糖水平降低,并激活PI3K/AKT信号传递.
VEGFB影响葡萄糖代谢的关键调节者.

结论:

VEGFB通过血管内皮生长因子受体1促进胰岛素介导的葡萄糖分泌.
通过VEGFB激活PI3K/AKT信号通路是调节IGT中葡萄糖代谢障碍的关键.
VEGFB代表了管理糖尿病前期和IGT的潜在治疗标.

关键词:

葡萄糖激素分泌的分泌物葡萄糖耐受性受损的情况.通过胰岛素介导的胰岛素.糖尿病前期:糖尿病前期.血管内皮生长因子B

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