激光吸收光谱测量不同肺氧气度的传导度和发送度几何:幻影研究
Andrea Pacheco1,2, Jean Matias1,2, Konstantin Grygoryev1
1Tyndall National Institute, Biophotonics@Tyndall, IPIC, Cork, Ireland.
Journal of biomedical optics
|December 11, 2023
概括
散射介质中的气体吸收光谱 (GASMAS) 技术显示出对监测早产婴儿肺功能有前途. 为了准确测量氧度,确定了最佳配置,可能取代X射线.
科学领域:
- 生物医学光学 生物医学光学
- 医学物理 医学物理
- 新生儿医学 新生儿医学
背景情况:
- 持续监测早产婴儿的肺功能对于临床管理至关重要.
- 目前的方法,如X射线诊断和血液氧化测量,在速度和间接性方面都有局限性.
- 散射介质中气体吸收光谱 (GASMAS) 技术提供了一个潜在的非侵入性替代方案.
研究的目的:
- 确定最佳的源探测器配置,以在GASMAS中可靠地计算路径长度.
- 为了估计新生儿肺幻象中的氧气度.
- 为了评估GASMAS在一系列氧度 (21-100%) 的性能.
主要方法:
- 使用了模拟新生儿胸部的人形光学幻影.
- 采集的GASMAS信号跨了30个源探测器配置在传输和发送几何.
- 测试了两种不同的几何形状和尺寸的幽灵,模仿新生儿解剖学.
主要成果:
- 内部照明给药产生了更高的GASMAS信号与噪声比率 (SNR).
- 较小的幽灵通常会导致更好的SNR.
- 路径宽度和氧度计算显示,820nm的变化较高,而764nm的变化较大.
结论:
- 通过优化配置的GASMAS技术,可以通过将源和探测器移动到胸部来评估大多数肺体积.
- 这种技术可能会减少在早产婴儿中需要X射线诊断的需要.
- GASMAS为直接,连续的肺功能监测提供了一个有前途的途径.
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