初级甲状腺淋巴瘤:预测扩散大B细胞淋巴瘤可能性的临床因素
Akifumi Kariya1, Tomoyasu Tachibana1, Yasushi Hiramatsu2
1Department of Otolaryngology, Japanese Red Cross Society Himeji Hospital, Himeji City, Hyogo, Japan.
Ear, nose, & throat journal
|December 11, 2023
概括
甲状腺中扩散性大B细胞淋巴瘤 (DLBCL) 的存活率低于惰性淋巴瘤. 超声波图案,如线性回声纤维和缺少结节图案,可以帮助区分DLBCL,这可能会导致气道狭窄.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 放射学 放射学是一门学科.
背景情况:
- 初级甲状腺淋巴瘤 (PTLs) 包含各种亚型,扩散性大B细胞淋巴瘤 (DLBCL) 与粘膜关联淋巴组织 (MALT) 和卵泡淋巴瘤 (FL) 等惰性淋巴瘤相比,预后更差.
- 区分DLBCL和惰PTL的临床区别和预测因素仍然不完全理解,需要进一步调查.
研究的目的:
- 在PTL队列中研究DLBCL和惰性淋巴瘤之间的临床差异.
- 确定特定的临床和超声波因素,可以区分DLBCL和惰的PTL.
主要方法:
- 从2005年至2022年期间治疗的28名PTL患者的医疗记录的回顾性分析.
- 收集的数据包括患者人口统计,症状,超声波检测结果,呼吸道状况 (CT和内镜),实验室结果和病理诊断.
- 采用多变量分析来确定DLBCL的独立预测因子.
主要成果:
- 组织学诊断包括13例DLBCL,12例MALT淋巴瘤和3例FL病例.
- 疾病特异性存活率显著低于DLBCL (68.2%),而不是惰性淋巴瘤 (100%,P = .043).
- 气道狭窄和乳酸脱酶水平升高仅在DLBCL患者中观察到. 超声波上线性回声链图案和缺少结节图案独立与DLBCL相关 (分别P=0.0497和0.012).
结论:
- 扩散性大B细胞淋巴瘤 (DLBCL) 与预后较差有关,并且可以导致一次性甲状腺淋巴瘤的气道狭窄.
- 特定的超声检测结果,即线性回声链图案的存在和结节图案的缺失,是DLBCL的重要预测因素,有助于将其与惰性甲状腺淋巴瘤区分开来.
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