获得超极化129Xe磁共振图像的肺透气
William J Garrison1, John P Mugler2, Jaime F Mata3
1Department of Biomedical Engineering, University of Virginia.
Journal of visualized experiments : JoVE
|December 11, 2023
概括
标准化超极化129XeMRI技术对于肺部成像至关重要. 本指南详细介绍了129XeMRI工作流程的最佳实践,确保机构之间一致和安全的肺透气成像.
科学领域:
- 医疗成像医学成像
- 肺部病理学 肺部病理学
- 磁共振成像技术 磁共振成像技术
背景情况:
- 超极化129XeMRI提供独特的肺部结构和功能成像.
- 标准化至关重要,因为FDA批准了129Xe,机构兴趣日益增长.
- 129Xe MRI 临床试验联盟 (Xe MRI CTC) 已经建立了最佳实践.
研究的目的:
- 为129XeMRI肺透气成像提供实用,端到端的工作流.
- 详细介绍 Xe MRI CTC 的建议,以确保数据采集的一致性.
- 引导研究人员和临床医生实施129XeMRI协议.
主要方法:
- 讨论了为MR研究准备和使用129Xe气体的方法.
- 涵盖了研究和个人扫描的最佳气体体积.
- 详细介绍受试者在扫描期间的安全监测和129Xe耐受性.
主要成果:
- 介绍了关键的MR技术考量,包括脉冲序列和参数.
- 解释了129Xe翻转角度和中心频率的校准.
- 包括129XeMRI通风图像分析的方法.
结论:
- 这项工作促进了标准化的129XeMRI工作流程的开发.
- 遵守 Xe MRI CTC 建议可确保可靠的肺通风成像.
- 实践指南支持129XeMRI的更广泛的采用和应用.
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