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Updated: Jul 8, 2025

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
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Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

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BLK通过催化TOLLIP酸化来积极调节TLR/IL-1R信号传输

Wei-Wei Li1,2,3, Xu-Xu Fan1,3, Zhi-Sheng Xu2

  • 1State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.

The Journal of cell biology
|December 11, 2023
PubMed
概括

收费类受体/介质素-1受体 (TLR/IL-1R) 信号传递对免疫非常重要. 这项研究揭示了BLK激酶通过酸化TOLLIP来激活这种途径,促进IRAK1解离和炎症反应.

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