被忽视的细菌大流行病
Danilo Gomes Moriel1, Diego Piccioli1, Maria Michelina Raso1
1GSK Vaccines Institute for Global Health, Via Fiorentina 1, 53100, Siena, Italy.
Seminars in immunopathology
|December 11, 2023
概括
抗微生物耐药性 (AMR) 构成重大威胁,反映了历史上的细菌大流行. 需要采取紧急行动,防止AMR成为下一次全球卫生危机.
科学领域:
- 微生物学 微生物学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 随着COVID-19的爆发,全球卫生领域的脆弱性得到了凸显.
- 历史上的细菌感染 (如瘟疫,霍乱) 深刻影响了人类文明.
- 有一种危险的误解,认为只有病毒威胁存在,忽视了细菌威胁和抗菌素耐药性 (AMR).
研究的目的:
- 通过审查它们的历史影响,强调细菌感染的流行病潜力.
- 为了突出抗菌素耐药性 (AMR) 的不断升级的危机.
- 讨论细菌突变,全球传播,疾病负担和控制措施.
主要方法:
- 关于由细菌引起的历史流行病的文献综述.
- 分析当前抗菌素耐药性 (AMR) 的趋势.
- 检查细菌突变机制及其流行病学影响.
主要成果:
- 从历史上看,细菌感染导致了毁灭性的流行病,并塑造了文明.
- 由于细菌突变,全球抗菌耐药性 (AMR) 正在增加.
- 如果没有干预,AMR可能成为全球最重要的健康挑战.
结论:
- 细菌感染,特别是那些涉及AMR的细菌感染,代表了一个显著而被低估的流行病威胁.
- 解决AMR需要采取多方面的方法,包括预防和治疗策略.
- 扭转AMR的趋势对于防止未来全球健康灾难至关重要.
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