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青少年体重指数和年轻成人早期慢性病
Avishai M Tsur1,2,3,4, Inbal Akavian1,2, Regev Landau1,2,3,4
1Israel Defense Forces, Medical Corps, Tel Hashomer, Ramat Gan, Israel.
JAMA pediatrics
|December 11, 2023
概括
青少年的高体重指数 (BMI) 与年轻成人早期慢性病 (CKD) 有关. 这种关联甚至在那些高正常BMI的人中也存在,这突显了管理青少年肥胖和脏健康的必要性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 公共卫生 公共卫生
- 青少年医学 青少年医学
背景情况:
- 青少年肥胖率的上升是一个重大的公共卫生问题.
- 早期检测与肥胖相关的脏后果对于长期健康结果至关重要.
- 关于青少年体重指数 (BMI) 和早期慢性病 (CKD) 之间的联系的数据有限.
研究的目的:
- 调查青少年BMI与年轻成人早期慢性病 (CKD) 的发展之间的联系.
- 在不同类别的青少年BMI中量化早期CKD风险.
主要方法:
- 一项大型队列研究将以色列青少年 (16至20岁) 的强制性医疗评估数据与国家CKD注册表联系起来.
- 排除标准包括先前存在的病理,白蛋白尿,高血压,失糖症或缺失的数据.
- 用年龄和性别匹配百分比来对BMI进行分类;随访延长到CKD早期发病或2020年8月.
主要成果:
- 该研究包括593660名青少年,其中1963人在平均随访13.4年期间发展为早期CKD.
- 在男性中,早期CKD的调整风险比与BMI增加:高正常 (1.8),超重 (4.0),轻度肥胖 (6.7) 和严重肥胖 (9.4).
- 在女性中也观察到类似的趋势,高正常BMI的危险比率从1.4增加到重型肥胖的4.3,而且这种风险存在于看似健康的个体和30岁之前.
结论:
- 青春晚期BMI升高与年轻成人早期CKD风险增加显著相关.
- 即使在具有高正常BMI的青少年中,患早期CKD的风险也存在,并且在肥胖患者中显著增加.
- 这些发现强调了解决青少年肥胖症和实施主动病风险管理策略的关键重要性.
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