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Updated: Jul 8, 2025

Preparation and Culture of Rat Lens Epithelial Explants for Studying Terminal Differentiation
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Preparation and Culture of Rat Lens Epithelial Explants for Studying Terminal Differentiation

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兰醇合成酶通过调节SREBP1在透镜上皮纤维化期间防止EMT

Pengjuan Ma1, Jingqi Huang1, Baoxin Chen1

  • 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.

Investigative ophthalmology & visual science
|December 11, 2023
PubMed
概括

兰醇合成酶 (LSS) 通过调节醇生物合成,保护透镜细胞免受纤维化. 这种酶和兰醇在治疗纤维性白内障方面表现有前途,通过预防上皮层-介质细胞过渡 (EMT) 来治疗纤维性白内障.

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相关概念视频

Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
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