辅助布里瓦拉和持续的发作频率降低在非常活跃的焦点
Simona Lattanzi1, Laura Canafoglia2, Maria Paola Canevini3,4
1Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy.
Epilepsia
|December 11, 2023
概括
布里瓦拉 (BRV) 在焦点的有效性因发作频率和先前治疗而有所不同. 较高的基线发作频率和更早的ASM预测BRV的响应率较低.
科学领域:
- 的研究研究.
- 神经系统疾病的药理疗法
- 临床神经学 临床神经学
背景情况:
- 焦点影响着全球众多个体,需要有效的辅助疗法.
- 布里瓦拉塞坦 (BRV) 是一种已知抗发作药物 (ASM),作为补充治疗.
- 患者对BRV的反应可能受到个人因素的影响,包括疾病严重程度和治疗史.
研究的目的:
- 为了评估布里瓦拉 (BRV) 在焦点患者的疗效.
- 为了确定基线发作频率和先前抗药物 (ASM) 史是否影响BRV有效性.
- 根据这些患者特征,分析持续性反应 (SSR) 和自由率 (SSF).
主要方法:
- 从BRIVAFIRST研究中对994名成年焦点患者进行了回顾性多中心分析.
- 患者接受了12个月的辅助BRV.
- 结果包括SSR,SSF,治疗中止和不良事件 (AE),按基线发作频率 (<5,5-20,>20/月) 和之前的ASM使用 (<5,≥6) 分层.
主要成果:
- 持续性发作反应 (SSR) 率随着基线发作频率更高 (45.8%至22.6%) 和更早的ASM (51.2%至26.5%) 降低.
- 持久性查自由率 (SSF) 在这些层面上也显示出类似的下降.
- 由于缺乏疗效而停止治疗的患者在>20次/月和那些有≥6次先前ASM的患者中较高;AE率在各组之间是可比的.
结论:
- 基线发作频率和之前抗药物 (ASM) 的数量是辅助布里瓦拉 (BRV) 治疗结果的显著预测指标.
- 这些因素应在启动焦性的BRV治疗时考虑,以管理患者的期望并优化治疗策略.
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