Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Azide-functionalized SpCas9 enables generation of site-selective and bioactive Cas9-siRNA conjugates.

Chemical communications (Cambridge, England)·2026
Same author

From grassroots to strategy: advancing laboratory sustainability at Utrecht university.

RSC advances·2026
Same author

Diels-Alder Click Chemistry as a Dynamic-Covalent Crosslinking Method in Spheroid-Encapsulating Hydrogels for Cartilage Engineering.

Advanced healthcare materials·2026
Same author

Dynamic, Tunable, Biocompatible: Functional Polymers Advancing Biomedical Innovation.

Biomacromolecules·2026
Same author

Reduced Ventral Tegmental Area GABA neuron output contributes to hyperactivity in the activity-based anorexia model in female mice.

Nature communications·2025
Same author

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery.

Journal of visualized experiments : JoVE·2025

相关实验视频

Updated: May 28, 2026

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
11:20

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation

Published on: August 30, 2017

7.5K

多功能点击链接器,在Redox触发时从纳米载体释放原生.

Erik R Hebels1, Stefanie Dietl1, Matt Timmers1,2

  • 1Division of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3508 TB, The Netherlands.

Bioconjugate chemistry
|December 11, 2023
PubMed
概括

我们开发了一种新的链接器,用于将治疗性附在纳米载体上,从而实现有效的药物输送和释放. 这种方法改善了类药物递送,并增强了瘤细胞的杀死.

更多相关视频

Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
09:12

Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods

Published on: May 11, 2018

6.9K
Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

1.0K

相关实验视频

Last Updated: May 28, 2026

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
11:20

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation

Published on: August 30, 2017

7.5K
Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
09:12

Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods

Published on: May 11, 2018

6.9K
Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

1.0K

科学领域:

  • 生物结合化学 生物结合化学
  • 纳米医学是一种纳米医学.
  • 药物输送系统 药物输送系统

背景情况:

  • 纳米载体增强药物循环,瘤吸收和释放动力学.
  • 治疗性受益于改进的输送策略,以提高其治疗指数.
  • 坐标共价连接器化学对于合成,纳米载体结合和触发释放至关重要.

研究的目的:

  • 开发一种用于将治疗性酸与纳米载体结合的新型链接器.
  • 为了促进在树脂上的生成,纳米载体结合,并触发本地的释放.
  • 为了研究一种新的链接-联系统在癌症治疗中的有效性.

主要方法:

  • 固相合成 (SPPS) 用于将一个无铜可点击链接器 (TMTHSI) 与解性体LTX-315结合.
  • 通过点击化学,将链接联物附加到含有亚酸的基化核心交联聚合物微粒 (CCPM) 上.
  • 使用谷氨的体外释放研究和对1,6-消除的分析.
  • 使用细胞培养的细胞毒性和细胞吸收研究.

主要成果:

  • 合成了一种新型链接剂,其中含有压缩的基因,二硫化键和乙烯基碳酸盐间隔剂,并与LTX-315结合.
  • 在水性条件下,水友性链接联体在50纳米的CCPM上有效地加载 (8质量%的负载,56%的效率).
  • 试验室研究表明,在暴露于谷氨时,LTX-315的快速释放,随后是1,6-消除,产生原生.
  • LTX-CCPMs对瘤细胞表现出强烈的细胞毒性,相当于自由的LTX-315.

结论:

  • 一个新的,直角链接系统使治疗性酸能够高效地与纳米载体结合.
  • 开发的纳米载体系统有效地提供和释放治疗性,增强抗癌活性.
  • 这种方法为改善基于的药物的治疗指数提供了一个有希望的策略.