在缺血-再输液模型中分析了来自肠道微生物群的脂质代谢物

Keita Nakatsutsumi1, Koji Morishita, Todd W Costantini

  • 1From the Trauma and Acute Critical Care Center (K.N., K.M. M.K., T.A., A.S., K.S.), Tokyo Medical and Dental University Hospital, Tokyo, Japan; Division of Trauma, Surgical Critical Care, Burns, and Acute Care Surgery, Department of Surgery (K.N., T.W.C.), University of California, San Diego, California; Department of Acute Critical Care and Disaster Medicine (M.K.), Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Emergency and Critical Care Center (M.K.), Tokyo Women's Medical University, Adachi Medical Center, Tokyo; Laboratory for Metabolomics (M.A.), RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa; Division of Physiological Chemistry and Metabolism (M.A.), Graduate School of Pharmaceutical Sciences, Keio University; and National Hospital Organization Disaster Medical Center (Y.O.), Tokyo, Japan.

概括

肠道缺血会增加肠道细菌衍生的脂质,如中肠淋巴中的酸和10-基-cis-12-octadecenoic acid (HYA). 这突显了肠道微生物群和创伤后多器官功能障碍 (MOD) 之间的联系.

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