在患有先天性心脏病的儿童中,中央SBP的纵向发展
Laura Willinger1,2, Leon Brudy1, Michael Meyer1
1Department of Congenital Heart Disease and Pediatric Cardiology, Deutsches Herzzentrum München.
Journal of cardiovascular medicine (Hagerstown, Md.)
|December 11, 2023
概括
在患有先天性心脏病 (CHD) 的儿童中,中央缩血压 (cSBP) 随着时间的推移显著增加. 这种cSBP的纵向上升需要进一步的研究和针对特定患者群体的专注监测.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 心血管生理学心血管生理学
- 纵向健康研究 纵向健康研究
背景情况:
- 中枢静脉压 (cSBP) 在患有先天性心脏病 (CHD) 的儿童中升高.
- 在小儿心血管疾病群体中,cSBP随时间的发展轨迹以前没有被研究过.
研究的目的:
- 纵向评估诊断为心脏病的儿童和青少年cSBP的自然过程.
- 为了确定影响cSBP在这个群体中的进展的因素.
主要方法:
- 一项前性纵向研究,涉及306名患有心脏病的儿童和青少年.
- 在平均 30.1 个月的随访期间,对cSBP进行非侵入性振荡计测量.
- 分析使用线性混合效应模型来确定cSBP趋势.
主要成果:
- 在患有心脏病的儿童中,cSBP显示每年显著增加1.22 mmHg.
- 在调整性别,BMI,药物,疾病严重程度和心血管疾病类型后,这种增加仍然显著.
- 在动脉切换后的大动脉转移 (TGA) 患者,肥胖儿童和男孩中观察到更高的cSBP增加.
结论:
- 这项研究证实了CHD儿童中cSBP的显著纵向增加.
- 需要进一步的研究来确定这些cSBP轨迹是否异常.
- 建议监测血管功能,特别是TGA患者和患有心脏病的肥胖儿童.
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