鲁II) 基于类的寡乙烯复合物作为光疗剂
Houston D Cole1, Abbas Vali1, John A Roque1,2
1Department of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, Texas 76019-0065, United States.
Inorganic chemistry
|December 11, 2023
概括
聚烯复合物与硫连接物显示出强大的光动力疗法 (PDT) 对黑色素瘤的作用. 复合体Ru-3T和Ru-4T表现出高光毒性和单点氧生成,Ru-4T在低氧条件下表现出强度.
科学领域:
- 协调化学 协调化学
- 摄影化学的使用.
- 光动力疗法 (PDT) 是一种光动力疗法.
- 药用无机化学 药用无机化学
背景情况:
- ((II) 聚烯基复合物被广泛研究为PDT的光敏化剂.
- 带有不同数量的硫环的连接配体可以调节它们的光物理和生物特性.
研究的目的:
- 系统地研究Ru(II) 聚烯基复合物 ([Ru(phen) 2 ((IP-nT) ]2+) 与0-4硫环 (IP-nT) 作为光敏感剂.
- 评估它们的电化学,光谱和光生物特性,以对其进行潜在的PDT应用.
主要方法:
- 合成和表征[) 2] 2+复合物.
- 电化学测量 (氧化和还原潜力).
- 光谱分析 (吸收,排放,时间解析吸收).
- 在可见光下对黑色素瘤细胞 (SK-MEL-28) 的光细胞毒性测定.
- 单一氧量子收益率的确定.
- 低氧性研究评估在低氧环境中的疗效.
主要成果:
- 电化学氧化潜力随着提奥芬单位 (n=1-4) 的增加而显著转移.
- 观察到高单点氧量子产量 (0.53-0.88),Ru-3T和Ru-4T是最有效的 (~0.88).
- 复合体Ru-2T-4T表现出长期存在的连接体内电荷转移 (3ILCT) 状态 (25-148 μs),与Ru-0T-1T不同,该复合体表现出短暂存在的金属到连接体电荷转移 (3MLCT) 状态.
- 摄影疗法疗效增加了提奥芬单位 (n=0-4),Ru-3T和Ru-4T显示出显著的功效 (在nM和pM范围内EC50).
- 在低氧 (1% O2) 条件下,Ru-4T表现出优越的光毒性和强度.
结论:
- 在Ru(II) 聚烯基复合体中,烯环的数量显著影响了它们的电化学,光谱和光细胞毒性.
- 复合物Ru-3T和Ru-4T是PDT的高效光敏化剂,可能是由于长期存在的3ILCT状态和高效的单片氧生成.
- Ru-4T显示为光动力学剂的承诺,即使在低氧环境中也保持有效性,突出其用于癌症治疗的潜力.
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