在大鼠中,肠道微生物组合的压力后变化具有不同程度的神经系统兴奋度
Alla Shevchenko1, Irina Shalaginova1, Dmitriy Katserov1
1Educational and Scientific Cluster "Institute of Medicine and Life Sciences (MEDBIO)", Immanuel Kant Baltic Federal University, Kaliningrad, Russia.
PloS one
|December 11, 2023
概括
神经系统兴奋性的遗传差异会影响压力下肠道微生物组的变化. 高值 (HT) 的老鼠菌株呈现出 Faecalibacterium 和 Prevotella 的增加,而这两种菌株在应激后减少了 Lactobacillus.
科学领域:
- 神经生物学 神经生物学 神经生物学
- 微生物组研究 微生物组研究
- 肠-大脑轴研究研究
背景情况:
- 肠-大脑轴是胃肠道和中枢神经系统之间的双向通信通道.
- 人们越来越认识到肠道微生物群的组成在神经系统的发育和功能中的作用.
- 压力引起的精神病理,如抑郁和焦虑,与肠道微生物群的改变有关,但遗传影响尚未完全理解.
研究的目的:
- 为了研究神经系统刺激性的遗传差异如何影响慢性压力下肠道微生物组合.
- 为了比较高值 (HT) 和低值 (LT) 鼠株之间的压力诱导的肠道微生物变化.
主要方法:
- 两种老鼠株 (HT和LT) 被长期的情绪和痛苦的压力 (Hecht协议).
- 在暴露于压力之前和之后收集了便样本.
- 肠道微生物组成使用16S rRNA amplicon测序进行了分析.
主要成果:
- 在HT和LT大鼠菌株之间观察到明显的肠道微生物多样性;HT大鼠表现出更高的多样性.
- 长期的压力导致HT大鼠菌株中Faecalibacterium和Prevotella的相对丰度增加.
- 无论是HT和LT的老鼠菌株都显示,在暴露于压力后,乳酸菌的丰度下降.
结论:
- 遗传性神经系统刺激性显著影响肠道微生物对压力的反应.
- 压力会改变肠道微生物群的组成,与特定菌株的变化.
- 对这些肠-大脑相互作用的进一步研究可能会为针对肠道微生物群的压力相关疾病提供新的治疗策略.
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