环开通转化聚合N-甲基二融合的诺博宁,以获得抗菌主链阴离子聚合物的聚合
Sarah N Hancock1, Nattawut Yuntawattana1, Emily Diep2
1Department of Chemistry, Texas A&M University, College Station, TX 77843.
概括
具有可调节结构的新型阴离子聚合物显示出强大的抗菌活性,对抗阴性和阳性细菌. 控制聚合物大小可以提高选择性,减少对人体细胞的伤害.
科学领域:
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
- 抗菌剂 抗菌剂 抗菌剂
背景情况:
- 性聚合物是有前途的抗菌剂,其活性受到结构修改的影响.
- 将cationic组放在聚合物核心附近可能会增强细菌对哺乳动物细胞的选择性.
- 对于主链 cationic 聚合物的传统合成方法缺乏精确的分子控制.
研究的目的:
- 开发一种可控聚合方法,用于合成具有可调节结构的主链阴离子聚合物.
- 研究这些新型聚合物的抗菌活性和选择性.
- 探索聚合物质量和血溶性活性之间的关系.
主要方法:
- 合成N-methylpyridinium-fused norbornene单体. 这种单体由N-methylpyridinium和N-methylpyridinium结合而成. 这种单体由N-methylpyridinium和N-methylpyridinium结合而成.
- 在优化条件下进行环开放元解聚合 (ROMP).
- 对抗大肠杆菌和耐美西林黄金葡萄球菌的抗菌功效的评估.
- 对人类红细胞的血液溶解活性的评估.
主要成果:
- 实现了良好的ROMP控制,使主链阴离子聚合物的结构多样化成为可能.
- 合成的多电解质表现出广泛的抗菌活性,最小的抑制度低至25μg/mL.
- 较低摩尔质量的聚合物表现出更好的选择性,与较高摩尔质量的对应物相比,显示出降低的溶血活性.
结论:
- 控制的ROMP提供了对分子调节的主链阴性聚合物的访问.
- 这些聚合物代表了一类具有可调节选择性的有前途的抗菌剂.
- 摩尔质量是优化cationic抗菌聚合物的安全性和有效性的关键参数.
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