基于Helicobacter pylori的人口研究:无症状感染是否意味着没有胃镜病变?
Ting Cai1,2, Ying Li3, Xin-Meng Li1,2
1Department of Gastroenterology, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha, Hunan 410013, China.
Postgraduate medical journal
|December 11, 2023
概括
杆菌 (H. pylori) 感染不会引起特定的症状,但会导致更严重的胃镜检测结果. 无症状的H. pylori患者的感染标记较低,但内镜检查结果类似,病变比未感染者更严重.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 临床诊断 临床诊断 临床诊断
背景情况:
- 杆菌 (H. pylori) 是一种常见的病原体,会影响上部胃肠道.
- 了解与H. pylori感染相关的临床谱和内镜发现对于患者管理至关重要.
- 需要特别注意无症状感染及其潜在的后果.
研究的目的:
- 为了确定H. pylori感染患者的常见临床特征.
- 为了研究H. pylori感染,临床症状和胃镜表现之间的关系.
- 专门分析无症状的H. pylori感染个体的临床特征.
主要方法:
- 在2018年1月至2020年12月期间,对2863名接受14C尿素呼吸测试的患者进行了回顾性分析.
- 收集人口统计数据,临床症状问卷和临床检查结果.
- 相关性分析以评估H. pylori状态,症状严重程度和内镜发现之间的关系.
主要成果:
- 总体的H. pylori感染率为26.30%.
- 在H. pylori阳性和H. pylori阴性组之间没有观察到临床症状的显著差异 (P > .05).
- 阳性H. pylori患者表现出明显更严重的胃镜表现 (P < .001).
- 14C尿素呼吸试验 (DPM) 的值与血清素和胃素-17水平相关.
- 较高的DPM值与症状组合的增加有关.
- 无症状的 H. pylori 阳性患者的 DPM 水平低于症状患者 (P < .001),但与 H. pylori 阴性患者相比,胃镜检测结果类似,病变更严重.
结论:
- 杆菌感染缺乏特定的胃肠道症状.
- 无症状的H. pylori感染的特点是较低的感染标志物 (DPM),但可与症状病例相比较的胃镜表现.
- 感染H. pylori的个体,包括无症状的个体,存在比H. pylori阴性个体更严重的内镜病变.
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