最近伦敦周围的氧化滥用事件激增,这值得公众健康警告
Naveed Malek1, Akın Nihat1, Miriam Mattoscio1
1Department of Neurology, Queen's Hospital, Romford RM7 0AG, United Kingdom.
Postgraduate medical journal
|December 11, 2023
概括
娱乐性氧化 (N2O) 滥用正在导致英国年轻人神经问题激增. 这项研究强调,迫切需要提高临床意识和监管行动,以防止N2O滥用造成进一步的伤害.
科学领域:
- 神经学 神经学
- 公共卫生 公共卫生
- 毒理学 毒理学 毒理学
背景情况:
- 娱乐性氧化 (N2O) 的使用在英国越来越引起公众健康的关注.
- 年轻人越来越被认为是受N2O滥用影响的人口.
研究的目的:
- 调查N2O毒性患者的人口统计,临床表现和治疗方法.
- 在四年内分析与娱乐性N2O使用相关的住院病人的趋势.
主要方法:
- 从埃塞克斯的一个神经中心的医院记录进行了回顾性分析.
- 纳入标准:在四年内入院的患者有N2O休使用毒性症状.
- 收集的数据:患者人口统计,呈现症状,神经学检查结果,生物化学测试和成像结果.
主要成果:
- 在2018年9月至2022年10月期间,有17名患者 (平均年龄为22.9岁) 住院,而2022年这一数字将大幅增加.
- 常见的症状包括四肢麻醉 (100%),失衡 (95%) 和客观四肢虚弱 (65%).
- 生物化学异常 (低维生素B12,甲基马龙酸和同氨酸升高) 和神经学发现 (MRI异常,神经传导研究表明神经病变) 普遍存在.
结论:
- 在英国,与娱乐性N2O滥用相关的神经并发症的显著增加已被观察到,特别是在2022年.
- 迫切需要提高临床医生和卫生监管机构对N2O毒性的认识.
- 积极的措施对于减轻与年轻人群的娱乐性N2O滥用相关的健康风险至关重要.
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