通过非热生物相容大气压等离子体改善皮肤间的吸收率
Byoung-Choul Kim1, Juie Nahushkumar Rana2, Eun Ha Choi3
1Department of Plasma Bio Display (PDP), Kwangwoon University, Seoul, 01897, South Korea.
Drug metabolism and pharmacokinetics
|December 11, 2023
概括
非热生物相容等离子体 (NBP) 显著增强氨胺的皮肤吸收. NBP治疗增加了60倍的通过皮肤传递,显示出用于化品和制药的应用的前景.
科学领域:
- 皮肤病学 皮肤病学
- 生物物理学的生物物理.
- 材料科学 材料科学 材料科学
背景情况:
- 非热生物相容等离子体 (NBP) 提供了增强局部药物递送的潜力.
- 当前的化品等离子器件通常使用浮电极源,皮肤作为接地电极.
研究的目的:
- 评估NBP对尼胺胺皮肤透性的影响.
- 量化通过皮肤吸收率与或没有NBP治疗.
主要方法:
- 通过使用人类皮肤样本进行了体外研究.
- 用NBP治疗12个小时后 (10秒持续时间) 测量了尼亚辛胺的通过皮肤吸收.
主要成果:
- 在0.5至6小时之间,NBP治疗显著增加了尼胺胺的皮肤透过吸收.
- 与未经处理的皮肤相比,使用NBP治疗的皮肤的透率是60倍.
- 增加的透持续了超过12个小时的治疗后.
结论:
- NBP治疗大大提高了皮肤的透性,使氨酸的输送.
- 由NBP诱导的血穿孔是增加吸收的主要机制.
- NBP是化品和制药局部输送系统的一个有前途的技术.
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