云南苗族群的母系遗传学见解,由完整的线粒体基因组揭示出来
Chong Chen1, Yuxin Guo2, Yating Fang3
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China; Department of Forensic Medicine, Faculty of Basic Medical Science, Chongqing Medical University, Chongqing 400016, China.
Gene
|December 11, 2023
概括
来自云南省的132名苗族人的基因分析揭示了他们与其他赫蒙族-苗族人群的密切联系,这表明古老的基因交换. 特定的母系系在新石器时代扩大,人口恢复约为0.5-1 kya.
科学领域:
- 人口遗传学 人口遗传学
- 人类进化遗传学 人类进化遗传学
- 古代DNA分析 古代DNA分析
背景情况:
- 苗族人,一个讲语的群体,有复杂的迁徙历史和独特的进化遗传学.
- 对苗族,特别是来自云南省 (YNM) 的遗传研究是有限的,特别是使用完整的线粒体基因组 (线粒体基因组).
研究的目的:
- 测序和分析来自云南省的132个Miao个体的完整线粒基因组.
- 综合调查YNM集团的遗传背景和人口史.
- 将YNM遗传数据与其他东亚人口进行比较,以了解他们的关系.
主要方法:
- 来自132个YNM个体的完整线粒体基因组的大规模并行测序.
- 获得的线粒基因组的哈普洛型和哈普洛组分析.
- 使用99个已发表的数据集 (7135个完整的线粒体序列) 进行人口基因比较分析.
- 人口动态建模以推断历史人口规模变化.
主要成果:
- 132个YNM个体产生了119个独特的单元型,主要是东南亚单元型 (B,F,M7,R9).
- YNM与赫蒙族,泰族,中藏族和奥地利亚裔人群,特别是赫蒙族,有着密切的遗传亲属关系.
- 特定的母系血统 (B5a1c1a,F1g1,B4a5,D4e1a3) 与其他赫蒙-米恩人群共享,表明新石器时代的扩张.
- 人口动态分析表明,人口减少1-5kya,随后恢复0.5-1kya,在恢复期间B5a1c1a扩张.
结论:
- 族群拥有独特的遗传特征,与其他族群密切相关.
- 有证据表明,苗族和古拜岳族之间可能存在基因流动.
- 特定的母系血统突出显示了新石器时代的蒙-米恩扩张时期的共同祖先和人口统计事件.
- 青年民族运动的人口经历了显著的人口变化,包括最近的复苏阶段.
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