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格陵兰环状海 (Pusa hispida) 的基因表达和微量元素

Joy Ometere Boyi¹, Christian Sonne², Rune Dietz²

¹Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine Hannover, Foundation, Büsum, Germany.

Environmental research

|December 11, 2023

概括

格陵兰岛的环状海积累了高水平的和,成年人显示出更高的度. 分子分析显示,这些微量元素与基因表达变化之间没有直接联系,这表明可能涉及其他压力因素.

科学领域:

海洋生物学海洋生物学
环境毒理学环境毒理学
北极的生态学北极的生态学

背景情况:

环状海,作为北极的顶级捕食者,生物放大环境污染物.
人类在北极活动的增加使环状海暴露在重金属中,导致生殖功能障碍和神经损伤等健康问题.
对于重金属对北极环状海对环境变化的分子影响的了解有限.

研究的目的:

为了研究格陵兰环状海中 (Cd), (Hg) 和 (Se) 的度.
分析与生物转化,氧化应激,内分泌干扰和免疫活动相关的分子生物标志物,以应对微量元素暴露.
探索微量元素水平和环状海中的分子反应之间的潜在相关性.

主要方法:

16只格陵兰环状海 (9个成年,7个未成年) 的肝脏中的,和的量化度.
在血液和脂肪中测量了包括ARNT,PPARα,ESR1,TRα,IL-2,HSP70和IL-10在内的生物标志物的mRNA转录水平.
统计分析了微量元素度与生物标记物基因表达之间的关系.

主要成果:

微量元素度按照以下顺序进行: > > ,在成年海中观察到更高的和水平.
对于ARNT,PPARα,ESR1,TRα和IL-2的mRNA转录水平在脂质中最高,而HSP70和IL-10在血液中显著更高.
在测量的微量元素度和分析生物标记物的mRNA转录水平之间没有发现显著的相关性.

结论:

该研究表明,除了研究的微量元素 (Cd,Hg,Se) 之外的其他因素可能是对格陵兰环状海中观察到的基因表达变化负责.
环状海中的含量升高表明需要加强对北极海种群的健康监测计划.
需要进一步的研究来确定影响环状海在不断变化的北极环境中的分子健康的特定压力因素.

关键词:

生物标志物生物标志物细胞因子 (cytokines) 是一种细胞因子.内分泌系统内分泌系统免疫反应的免疫反应.水星水星水星水星水星金属金属金属

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