相关实验视频

Updated: Jul 8, 2025

Isolation of Mouse Coronary Endothelial Cells
07:36

Isolation of Mouse Coronary Endothelial Cells

Published on: July 3, 2016

11.3K

乌洛科丁2通过调节巨细胞外细胞囊泡来减轻糖尿病冠状动脉微血管功能障碍

Chao Zhu1, Lihua Pan1, Feier Zhou1

  • 1Department of Pharmacology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, China.

Biochemical pharmacology
|December 11, 2023
PubMed
概括

来自巨细胞的甲基醇暴露的小细胞外囊泡在糖尿病中诱导冠状动脉微血管功能障碍 (CMD). 乌洛科丁2 (UCN2) 通过调节巨细胞衍生的囊泡并恢复IL-33水平来保护糖尿病CMD.

关键词:
冠状动脉微血管功能障碍 冠状动脉微血管功能障碍糖尿病 糖尿病 糖尿病脑内皮质 (Endothelium) 是一个内皮质.巨细胞是一个巨细胞.小小的细胞外囊泡.在UCN2中,UCN2是UCN2.

更多相关视频

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice10:37

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

163
MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues12:21

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

15.0K

相关概念视频

Insulin Secretory Vesicles01:05

Insulin Secretory Vesicles

Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
5.0K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
2.1K
Role of ER in the Secretory Pathway01:17

Role of ER in the Secretory Pathway

Eukaryotic cells have a special pathway that enables communication between various intracellular membrane-bound compartments and also with the extracellular environment. This pathway is termed as the secretory pathway.
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
5.4K