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在体感神经元中介质10信号传递控制CCL2释放和炎症反应

Sabrina de Souza¹, Jesús Rosario Claudio¹, Jaewon Sim¹

¹Department of Physiology, Michigan State University, East Lansing, MI, USA.

Brain, behavior, and immunity

|December 11, 2023

概括

介质素-10 (IL-10) 通过与感觉神经元上的受体结合来限制炎症,降低C-C动机化学因子连接体2 (CCL2) 的调节,并减少免疫细胞的吸引力. 这揭示了涉及感官神经元的新型抗炎途径.

科学领域:

神经免疫学神经免疫学
炎症研究炎症研究
感官神经元生物学感官神经元生物学

背景情况:

适当调节炎症反应对于生存至关重要.
介素-10 (IL-10) 是一种关键的抗炎细胞因子.
IL-10受体 (IL-10R1) 表达在背部根结节 (DRG) 感觉神经元上,这表明它在免疫调节中的作用.

研究的目的:

研究IL-10信号在DRG神经元中调节炎症反应中的作用.
为了确定感觉神经元上的IL-10R1是否通过化学因子影响免疫细胞的贩运.

主要方法:

使用了缺乏IL-10R1的转基因小鼠,特别是在advillin阳性神经元中.
使用脂多糖 (LPS) 诱导全身炎症,并分析了各种生理和分子标记物.
进行DRG神经元初级培养,以评估IL-10R1对化学和神经产生的影响.

主要成果:

在感觉神经元上缺乏IL-10R1的小鼠表现出夸张的炎症反应,包括血中氧化的增加,脊髓微质激活和全身细胞因子上调.
在DRG和三腺 (TG) 神经元中IL-10R1的删除导致了亲炎性化学C-C动机化学联体2 (CCL2) 的水平升高.
发现DRG神经元中的IL-10R1信号抑制了CCL2的产生,独立于TRPV1,P物质或CGRP.

结论:

直接向感觉神经元发送信号的IL-10降低了CCL2的产生,从而限制了免疫细胞的招募,并有助于解决炎症.
这项研究提供了第一个证据,即抗炎细胞因子可以直接作用于感觉神经元来控制炎症.
感官神经元具有重要的免疫调节功能,超出了它们在疼痛和感觉中的传统作用.

关键词:

在CCL2中,我们可以使用CCL2.细胞因子细胞因子 DRG 感官神经元的感官神经元.炎症炎症是一种炎症.互白素-10 (IL-10) 是一种蛋白质.在LPS中使用LPS.这是神经免疫系统.

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