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在高脂肪饮食下食用大麦可以通过改变肠道胆酸成分来抑制脂原基因
Kento Mio1, Naoko Iida-Tanaka2, Marina Togo-Ohno3
1Graduate School of Studies in Human Culture, Otsuma Women's University, Tokyo, Japan; Research and Development Department, Hakubaku Co., Ltd., Yamanashi, Japan.
The Journal of nutritional biochemistry
|December 11, 2023
概括
麦麦粉的消费,富含β-葡萄糖,通过改变胆酸代谢,有助于防止脂肪积累. 这种饮食变化会影响脂质水平和肝脏和肠道中的基因表达.
科学领域:
- 营养科学 营养科学
- 代谢健康 代谢健康
- 胃肠病学 胃肠病学
背景情况:
- 高脂肪饮食有助于脂质积累和代谢障碍.
- 食纤维,如大麦中的β-葡萄糖,可以调节宿主新陈代谢.
- 胆汁酸在调解饮食对脂质代谢的影响中的作用需要进一步阐明.
研究的目的:
- 为了研究大麦面粉消费对高脂肪饮食的小鼠脂质代谢的影响.
- 确定胆酸信号传递在调解大麦对脂质代谢的影响中的作用.
- 探索肠道微生物群对大麦代谢效应的影响.
主要方法:
- 在12周的时间里,小鼠被食高脂肪饮食,并添加纤维素或大麦粉.
- 用GC/MS分析胆酸组成.
- 与胆汁酸和脂质代谢相关的基因表达通过RT-PCR测量.
- 研究包括抗生素治疗,以评估微生物群的参与.
主要成果:
- 与纤维素相比,大麦面粉的摄入降低了肝脏胆固醇和甘油三水平.
- 初级胆汁酸减少,而二次胆汁酸增加在肠道与大麦消费.
- 大麦的摄入激活了FXR和TGR5信号通路,导致低调的脂质合成基因表达.
- 抗生素治疗减少了大麦观察到的代谢益处.
结论:
- 吃大麦面粉可以通过调节肠道中的胆酸概况来防止脂质的积累.
- 大麦对脂质代谢的影响取决于肠道微生物群的活性.
- 富含大麦的饮食可能提供一种通过胆酸信号管理代谢健康的策略.
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