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Wujun Chen¹, Yudong Wu¹, Jie Wang¹

¹Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao Cancer Institute, Qingdao, Shandong 266000, China.

Pharmacology & therapeutics

|December 11, 2023

概括

素C (TNC) 在瘤中过度表达,是药物输送的目标. 各种TNC结合剂,包括抗体-药物结合剂和放射性核素-药物结合剂,在癌症治疗方面表现有前途,并正在推进临床试验.

科学领域:

在瘤学瘤学.
生物技术是生物技术.
药物开发药物开发

背景情况:

素C (TNC) 是一种在瘤细胞外基质 (ECM) 中高度表达的糖蛋白.
在正常组织中,TNC在很大程度上不存在,这使得它成为癌症治疗的具体目标.
已经开发了许多TNC向剂,包括抗体,体和纳米体.

研究的目的:

提供关于特纳辛C (TNC) 结合剂药物的临床进展的全面审查.
为开发针对TNC的瘤治疗提供及时的信息.
突出基于跨国公司的药物输送系统的历史前景和未来潜力.

主要方法:

对TNC结合剂的临床前和临床试验数据的审查.
对各种TNC向分子的分析,包括抗体,,体和纳米体.
对TNC结合剂的分类,如抗体-药物结合剂 (ADC),抗体片段-药物结合剂 (FDC),免疫刺激抗体结合剂 (ISAC) 和放射性核素-药物结合剂 (RDC).

主要成果:

许多TNC抗体和aptamer已经在人体组织中进行了测试.
一些TNC结合剂,包括ADC,FDC,ISAC和RDC,已在临床前和临床环境中进行了研究.
像G11-iRGD和SMART这样的特定药物是临床试验的潜在候选者,因为它们的成分已经在临床研究中.

结论:

TNC结合剂代表了一类有希望的向癌症治疗药物.
基于TNC的药物的历史进展表明,在药物输送方面取得了重大进展.
继续开发TNC结合剂具有改善瘤向药物开发和临床结果的潜力.

关键词:

交付矢量是一个交付矢量.这些ISAC是ISAC.区域发行委员会 (RDCs) 是一个区域发行委员会.跨国跨国公司 (TNC) 是一个跨国公司.癌症发展代理商的发展代理商

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