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2年内富含核桃的饮食改变了健康老年人的血清氧化蛋白概况

Montserrat Cofán¹, Antonio Checa², M Serra-Mir³

¹Lipid Clinic, Endocrinology and Nutrition Service, Institut d'Investigacions Biomèdiques August Pi Sunyer, Hospital Clínic, Barcelona, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.

The Journal of nutrition

|December 11, 2023

概括

核桃的消费会改变老年人中的氧利平蛋白,增加有益的化合物,减少有害的化合物. 这项研究提供了新的证据,证明核桃有保护心脏的好处.

科学领域:

心血管科学心血管科学
营养科学营养科学
代谢学代谢学代谢学

背景情况:

来自多不和脂肪酸 (PUFA) 的氧利平是心血管疾病和衰老的关键媒介.
虽然众所周知,鱼油的n-3PUFAs产生抗炎性氧利平,但关于植物衍生α-烯酸 (ALA,C18:3n-3) 的数据有限.
核桃是 ALA 的重要饮食来源.

研究的目的:

为了检查两年来健康的老年人果 (15%能量) 丰富的饮食对血清氧利平蛋白概况的影响.
为了比较一个富含核桃的饮食与对照饮食对特定氧利平度的影响.

主要方法:

一项随机对照试验涉及115名健康的老年人 (63-79岁),他们被分配给子丰富的饮食或对照饮食2年.
使用超高性能液体染色学-并联质谱法量化血清氧利平 (n=53).
测量红细胞ALA水平以确认饮食遵守.

主要成果:

与对照组相比,富含核桃的饮食显著增加了红细胞ALA水平.
核桃的消费导致了三种来自ALA的氧利平 (9-HOTrE,13-HOTrE,12,13-EpODE) 和一种来自EPA的氧利平 (14,15-diHETE) 的显著增加.
核桃饮食还导致了特定的酸衍生氧利平素 (5-HETE,19-HETE,5,6-diHETrE) 的显著减少.

结论:

长期食用核桃会显著改变健康老年人的血清氧利平蛋白概况.
这些发现为归因于核桃的心脏保护作用提供了新的机制性见解.

关键词:

阿拉基酸是一种生物标志物生物标志物饮食饮食饮食饮食这是一种炎症炎症炎症炎症.脂质组的类型是什么在 n-3 中,n-3 是 n-3 的值.坚果和坚果是什么?坚果和坚果是什么?欧米茄-3 脂肪酸-3 脂肪酸植物性食品是一种植物性食品.α-烯酸-烯酸是什么?

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