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Updated: Jul 8, 2025

Measurement of Insulin- and Contraction-Stimulated Glucose Uptake in Isolated and Incubated Mature Skeletal Muscle from Mice
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一种ADAM17选择性抑制剂通过激活AMPKK来促进葡萄糖吸收

Tsugumasa Toma1, Nobukazu Miyakawa2, Mika Tateishi1

  • 1Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto, 862-0973, Japan.

Journal of pharmacological sciences
|December 11, 2023
PubMed
概括

新型ADAM17抑制剂SN-4激活AMPK,增强葡萄糖吸收和脂质代谢. 在没有引起乳酸或增加TNF-α释放的情况下,SN-4显示出作为抗糖尿病药物的潜力.

关键词:
一个分解蛋白和金属蛋白酶17 (ADAM17)AMP-激活蛋白激酶 (AMPK) 的使用糖尿病 糖尿病 糖尿病葡萄糖输送器类型4 (GLUT4)瘤死亡因子α (TNF-α)

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