相关实验视频

Updated: Jul 8, 2025

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages

Published on: June 2, 2020

跨物种发育组织动态的原型和缩放

Yoshihiro Morishita^1,2, Sang-Woo Lee³, Takayuki Suzuki⁴

¹Laboratory for Developmental Morphogeometry, RIKEN Center for Biosystems Dynamics Research, Kobe, 650-0047, Japan. yoshihiro.morishita@riken.jp.

Nature communications

|December 11, 2023

概括

这项研究揭示了在和青的四肢发育过程中保存的组织动态. 数学模型显示了形态遗传缩放和器官形状形成背后的物种独立原则.

科学领域:

发育生物学是发展生物学.
数学生物学的数学生物学
比较解剖学的比较解剖学.

背景情况:

形态测量研究表明动物形状中的几何关系.
器官/身体形状形态发生的数学原理在很大程度上是未知的.
不同物种的四肢形态发生为研究发育动态提供了一个模型.

研究的目的:

研究Gallus gallus domesticus () 和Xenopus laevis (非洲爪) 肢体形态发生背后的数学原理.
将不同种类的不同尺寸,形状和发育速度的组织变形动态进行比较.
建立跨物种发育时间的同步,以分析保存的形态遗传原理.

主要方法:

引入了一种特定物种的重新缩放的空间坐标系统.
开发了一种共同的时钟,以同步跨物种的发育时间.
分析了使用这些时空坐标的组织变形动态.

主要成果:

根据拟议的时空坐标系,在和青四肢发育过程中保持了组织动态.
保存动态从早期发展通过基本的数字模式观察到.
特定物种的组织动态通过物理空间的时间变量线性转换相互映射.

结论:

提出了形态发生过程中组织动态的物种独立原型的假设.
表明形态遗传缩放的基本原则在物种之间得到保护.
突出了重新缩放坐标和同步时钟对比较发育研究的有用性.

更多相关视频

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Published on: October 17, 2011

Surgical Size Reduction of Zebrafish for the Study of Embryonic Pattern Scaling

Surgical Size Reduction of Zebrafish for the Study of Embryonic Pattern Scaling

Published on: May 3, 2019

相关概念视频

Gastrulation

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...