在意大利多发性硬化症队列中对肠道功能障碍的多尺度评估
Eleonora Tavazzi1, Antonio Zito2, Cristina Montomoli3
1IRCCS Fondazione Istituto Neurologico C.Mondino, Via Mondino 2, 27100, Pavia, Italy. eleonora.tavazzi@mondino.it.
肠道功能障碍影响了超过一半的多发性硬化症患者,影响了他们的生活质量. 这些症状在进展性多发性硬化时更严重,并且与疾病的残疾和持续时间相关.
科学领域:
- 神经学 神经学
- 胃肠病学 胃肠病学
背景情况:
- 肠道功能障碍 (BD) 是多发性硬化症 (MS) 中常见但未被报告的问题.
- 现有的评估尺度可能无法完全捕捉MS患者便秘和便失禁的复杂性.
- 准确地描述BD对于临床管理和科学理解至关重要.
研究的目的:
- 确定患有多发性硬化 (pwMS) 的人群中肠道功能障碍的患病率.
- 用验证的尺度分析BD症状的严重程度和特征.
- 调查BD和MS疾病特征之间的关联.
主要方法:
- 招募了447名pwMS (330名复发性复发性MS,117名进展性MS).
- 使用神经性肠道功能障碍评分 (NBDS),韦克斯纳便秘量表 (WexCon) 和韦克斯纳失禁量表 (WexInc).
- 分析了与MS类型,疾病持续时间和残疾 (EDSS) 相关的BD患病率和得分.
主要成果:
- 肠道功能障碍 (NBDS>0) 在53.7%的pwMS中存在.
- 平均分数:NBDS 2.6 ,WexInc 1.1 ,WexCon 4.4.4 . 这就是我们的平均分数.
- 与复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发性复发.
- 疾病严重程度与疾病持续时间,EDSS和MS严重程度得分 (p < 0.001) 有显著的相关性.
结论:
- 肠道功能障碍在MS患者中非常普遍,跨越各种残疾水平.
- 渐进的MS表型和增加的临床残疾与更严重的肠道功能障碍有关.
- 这些发现凸显了在MS护理中需要定期查和管理BD的必要性.
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