检查在怀孕期间使用乙氨基与儿童早期语言发育的关系
Megan L Woodbury1,2,3, Patricia Cintora4, Shukhan Ng4
1Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL, USA. m.woodbury@northeastern.edu.
在怀孕期间使用乙氨基,特别是在第二和第三个三个月,可能与儿童早期语言发育不佳有关. 这种关联在男婴中更为明显,突出了潜在的神经发育问题.
科学领域:
- 神经发育研究的神经发育研究.
- 儿科语言发展指南
- 产前暴露研究 产前暴露研究
背景情况:
- 乙氨基是唯一一种在怀孕期间被认为安全的止痛药.
- 新出现的证据表明,产前乙氨基暴露可能与不良的神经发育结果相关.
- 有限的研究专门研究了它对儿童语言发展的影响.
研究的目的:
- 调查产前使用乙氨基与早期语言发育之间的关联.
- 检查两个不同的发育阶段 (26.5-28.5和36-38个月) 的语言结果.
- 探索这种关联中潜在的基于性别的差异.
主要方法:
- 潜在的出生队列研究 (伊利诺伊州儿童发展研究).
- 注册了532名新生儿,并提供了可用的暴露数据.
- 通过麦克阿瑟-贝茨沟通发育库存 (CDI) 和语音和语言评估量表 (SLAS) 收集了跨妊娠和语言数据的乙氨基暴露数据.
主要成果:
- 在第二或第三个三个月增加的乙氨基使用与较小的词汇量和较短的发言长度在26.5-28.5个月相关联.
- 第三个三个月的使用与男性婴儿中低于平均发言长度的更高几率有关.
- 产前对乙氨基的暴露与36-38个月的语言评估得分较低有关,特别是在男性中.
结论:
- 更高的产前乙氨基暴露,特别是在怀孕晚期,可能与早期语言发育受损有关.
- 观察到的效应在男孩中更为显著.
- 这项研究强调,需要进一步评估乙氨基对胎儿神经发育的影响.
更多相关视频
05:13Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
Published on: February 28, 2025
03:19Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
Published on: June 28, 2024
相关概念视频
Language Development
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
Teratogenicity
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Factors Affecting Drug Response: Overview
Phase II Reactions: Acetylation Reactions
The substrates for acetylation are typically drugs or their metabolites with an amino, sulfonamide, or hydrazine functional group. Acetylation can occur at several points in the drug molecule, including primary, secondary, and...
Language and Cognition
