高眼内压与非病理性高近视儿童的轴向生长减缓有关
Fabian Sl Yii1,2, Mingguang He3,4,5, Francesca Chappell6
1Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK. fabian.yii@ed.ac.uk.
Eye (London, England)
|December 11, 2023
概括
较高的眼内压力 (IOP) 与高近视儿童的轴延长速度较慢有关. 这一发现表明,眼部合规性可能会影响小儿高近视的内视压力和近视进展.
科学领域:
- 眼科医生 眼科 眼科
- 儿科眼科医生 儿科眼科医生
- 近视研究 近视研究
背景情况:
- 儿童高近视是一个越来越令人担忧的问题.
- 了解影响轴延长的因素对于近视管理至关重要.
- 眼内压力 (IOP) 是儿童高近视进展的一个潜在的,但尚未研究的因素.
研究的目的:
- 调查眼内压力 (IOP) 和高近视儿童轴延长率之间的关联.
- 同时探索IOP和轴长 (AL) 之间的关系.
主要方法:
- 一项对81名7至12岁高近视儿童 (162只眼睛) 的纵向研究.
- 使用线性混合效应模型 (LMM) 来分析五次两年一次访问的数据 (平均随访时间为5.2年).
- 对包括性别,年龄,中角膜厚度,前腔深度和透镜厚度在内的共变量进行控制.
主要成果:
- 较高的IOP与较慢的轴延长率显著相关 (β = -0.01,p = 0.001).
- 在IOP和轴长 (AL) (β = 0.03,p = 0.004) 之间发现了积极的同时关联.
- 这种IOP-AL关联随着年龄的增长而减弱,显著的相互作用效应表明 (β = -0.01,p = 0.001).
结论:
- 眼内压升高与高近视儿童的轴向生长减少相关.
- 这些发现表明,眼部合规可能在观察到的IOP-IOP关联中起着混作用.
- 这项研究有助于了解影响儿童近视进展的因素的复杂相互作用.
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