在炎症性疾病中IL-18的生物学和临床作用
Emily Landy1, Hallie Carol2,3, Aaron Ring4
1Program in Microbiology and Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Nature reviews. Rheumatology
|December 11, 2023
概括
介素-18 (IL-18) 在炎症和免疫系统中表现出复杂的作用. 在某些自身炎症性疾病中,IL-18的失调是关键,使得有针对性的治疗和诊断成为可能.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞因子生物学 细胞因子生物学
- 炎症研究 炎症研究
背景情况:
- 介素-18 (IL-18) 是IL-1家族的细胞因子,已知可以诱导干扰因子- (IFNγ).
- 最近的发现强调了IL-18复杂的致病潜力和临床相关性,超出其传统作用.
- 独特的IL-18生物特征影响其在粘膜和全身炎症中的多种作用.
研究的目的:
- 探索IL-18在健康和疾病中的多方面的作用.
- 研究IL-18失调的诊断和治疗影响.
- 了解IL-18对特定免疫细胞的影响及其在癌症免疫治疗中的潜力.
主要方法:
- 对IL-18转录,激活,分泌和信号通路的分析.
- 血液生物标志物研究以确定IL-18升高和"自由IL-18"水平.
- 在人类和动物模型中研究IL-18对CD8+T细胞和其他淋巴细胞的影响.
- 评估用于癌症免疫治疗的IL-18激动剂治疗方法.
主要成果:
- IL-18的严重升高,可检测到"自由的IL-18",是特定的自身炎症性疾病 ("IL-18病变") 的特征.
- 在这些情况下,IL-18失调是主要的驱动因素,这表明诊断特异性.
- 与其他对IL-18敏感的淋巴细胞相比,IL-18优先激活CD8+T细胞.
- IL-18激动剂疗法在增强抗癌免疫反应方面表现有前途.
结论:
- IL-18独特的生物学支持其在精确诊断中的显著临床影响.
- 对于监测炎症性疾病和指导向治疗来说,IL-18水平和失调是至关重要的.
- 有针对性的IL-18阻断或激应为炎症和恶性疾病提供了新的治疗途径.
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