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Updated: Jun 29, 2026

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一个新的小鼠线的特征,触发了过渡性寡细胞前代物衰竭

B Brousse1, O Mercier1, K Magalon1

  • 1Aix Marseille Univ, CNRS, IBDM UMR7288, Case 907, Parc Scientifique de Luminy, 13288, Marseille Cedex 09, France.

Scientific reports
|December 11, 2023
PubMed
概括

在成年小鼠中过渡性耗尽的寡头细胞前代细胞 (OPCs) 导致行为缺陷和大脑活动的改变. OPCs的恢复恢复了正常功能,这表明这些细胞具有神经调节作用.

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To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.