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化疗引起的外周神经毒性的非药物治疗:随机对照试验的网络元分析

Xia Zhang^1,2, Ao Wang^1,2, Miaowei Wang^1,2

¹Rehabilitation Medicine Center, Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.

|December 11, 2023

概括

按摩是治疗化疗引起的外周神经毒性 (CIPN) 的最有效的非药物治疗方法,可显著缓解疼痛并改善神经病理症状. 这一发现为寻求缓解化疗副作用的CIPN患者提供了有前途的干预措施.

科学领域:

在瘤学瘤学.
神经学神经学
综合医学是一个整体的医学.

背景情况:

化疗诱导的周围神经毒性 (CIPN) 是癌症治疗的常见和衰弱的副作用.
目前,缺乏有效的干预措施来预防和治疗CIPN.
非药物疗法显示有前途,但它们的比较有效性尚不清楚.

研究的目的:

确定最有效的非药物治疗方法来管理CIPN.
为了比较各种非药物干预措施对CIPN症状的疗效.

主要方法:

进行了随机对照试验 (RCT) 的系统审查和网络元分析.
在主要的数据库中进行了搜索:PubMed,科学网,Embase和Cochrane图书馆.
主要结局包括疼痛和神经病理症状;次要结局是生活质量和感觉/运动症状.

主要成果:

与针,维生素/加巴丁,常规护理和安慰剂相比,按摩在缓解疼痛方面表现出更高的疗效.
按摩比常规护理,感官运动训练,电刺激,多式运动和抵抗训练在减轻外围神经病理症状方面更有效.
与其他干预措施相比,按摩也显著改善了生活质量,以及感官和运动症状.

结论:

按摩成为CIPN的高效非药物干预措施,为疼痛,神经病理症状和生活质量提供了显著的好处.
虽然有希望,但由于研究的局限性,研究结果应谨慎解释.
未来的研究应该集中在高质量的多臂RCT上,以获得非药物干预的直接比较有效性.

关键词:

一个辅助的辅助.化疗化疗是一种化学疗法.周围神经系统疾病周围神经系统疾病随机对照试验是随机对照试验.

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